Synthesis, characterization and anticancer activity of new 2-acetyl-5-methyl thiophene and cinnamaldehyde thiosemicarbazones and their palladium(II) complexes

Abstract New thiosemicarbazone (TSC) ligands, AMT-C N-TSCH (L1), N-TSC(CH3) (L2), CIN-C (L3) and (L4) (AMT = 2-acetyl-5-methylthiophene, TSCH = thiosemicarbazide, TSC(CH3) = 4-methyl-3-thiosemicarbazide, CIN = cinnamaldehyde) were synthesized by condensation reaction. The reaction of [PdCODCl2] with the ligands L1, L2 L4in ratio 1:1 yielded complexes [Pd(L1)Cl] (C1), [Pd(L2)Cl2] (C2), [Pd(L4)2Cl2] (C4) respectively (COD = 1,5-cyclooctadiene). [Pd(COD)Cl2] in 1:2 metal to ligand complex [Pd(L3)2] (C3). characterized UV–Vis, FT-IR, NMR, elemental analysis conductivity measurements. L1 coordinated a tridentate fashion while L2, L3 L4 bidentate fashion. as thiol anions via thione sulphur. Conductivity measurements dimethyl sulfoxide showed that chloride ions C1, C2 C4 are within coordination spheres. crystal structures obtained from Bruker Smart KAPPA APEXII DUO diffractometer graphite monochromated Mo K?radiation (k = 0.71073 A). Cytotoxic activity compounds was investigated against human cancer cell lines; Caco-2 (colon), HeLa (cervical), Hep-G2 (hepatocellular), MCF-7 (breast), PC-3 (prostate) MCF-12A (non-cancer breast) cells. exhibited excellent broad spectrum growth inhibition all lines tested except for non-cancer breast All inhibited proliferation prostate cell.